Resources for Toxicologists—American College of Toxicology

Toxicology

Toxicology Tutorials from the US Department of Health & Human Services—ToxTutor is a self-paced tutorial covering key principles of toxicology for users of the National Library of Medicine (NLM) chemical and toxicology databases.
National Toxicology Program (NTP) of DHHS, NIH, NIEHS—NTP is an interagency program that evaluates agents of public health concern to understand the toxicology and thus identify hazard/risk, by developing and applying tools of modern toxicology and molecular biology.
National Institute of Health Toxicology data (TOXNET)—A listing of searchable databases providing information on hazardous substances, drugs, and other chemicals; includes DART, genomics, household products, risk assessment and animal alternatives.
EPA Computational Models—Search engine for over 100,000 computational models.
Toxicology Education Foundation—Nonprofit charitable foundation whose mission is to enhance public understanding of toxicology through access to objective, science-based information on the safety of chemicals and other agents encountered in daily life.
Toxicology in Wikipedia—Free content encyclopedia.

Chemistry

Chemistry Online Education—Basic and general chemistry information
Chemspider—Free chemical structure database providing text and structure search access to over 35 million structures from hundreds of data sources.
Chemblink—Online database of chemicals from around the world.

General Science Information

PubMed—Search engine for published data, scientific journals, MEDLINE, and online books (PUBMED search).
Science of Chemical Safety—Essential Toxicology from IUPAC (International Union of Pure and Applied Chemistry.) The presentations compiled are intended to provide educators with a resource of materials for teaching and learning the fundamentals of toxicology.
Science.gov—Science.gov searches over 60 databases and over 2,200 scientific websites to provide users with access to more than 200 million pages of authoritative federal science information including research and development results.
Science News—Search tool for science news. Science News offers readers a concise, current and comprehensive overview of the latest scientific research in all fields and applications of science and technology.
Science Watch—An open Web resource for science metrics and research performance analysis. Highlights the important role of research evaluation and management in support of strategic decision making.
Henry Stewart Talks Online Collections—Online seminars by leading world experts covering biomedicine, life sciences and many more topics.
Allen Brain Atlas—A data portal for brain information.
F1000 (Faculty of 1000)—Provide scientists access to recommended scientific literature—peer-reviewed by other experts—as an open forum to publish/discuss material.
ClinicalTrials.gov—Registry and results database of publicly and privately supported clinical studies conducted around the world.

Regulatory Agencies—Therapeutics

US FDA Center for Drug Evaluation and Research—Includes basic information about drugs, drug recalls, approvals, and news & events.
FDA NDC (National Drug Code) Directory—The Drug Listing Act of 1972 requires registered drug establishments to provide the FDA with a current list of all drugs manufactured, prepared, propagated, compounded, or processed by it for commercial distribution. This site facilitates a search for drug information by ‘Name’ or ‘Type’ (proprietary name, application number, active ingredient, NDC number, Labeler.)
US FDA Center for Devices and Radiological Health —information on medical device products, safety, advice, research, and news.
European Medicines Agency—Decentralized agency of the European Union (EU) responsible for the scientific evaluation of medicines developed by pharmaceutical companies for use in the EU.
US FDA National Center for Toxicological Research—NCTR conducts scientific research to generate data for FDA decision making, and develops and supports innovative tools and approaches that FDA uses to protect and promote individual and public health. Provides interdisciplinary toxicology research solutions and consultations that support and anticipate future FDA needs to guard and improve personal and public health.
UK Medicines and Healthcare products Regulatory Agency—The Medicines and Healthcare products Regulatory Agency regulates medicines, medical devices, and blood components for transfusion in the UK. MHRA is an executive agency, sponsored by the Department of Health.
Health Canada guidance documents—Guidance documents to assist in the interpretation of policies and governing statutes and regulations. They are intended to assist in preparing drug submissions when seeking an approval to sell a drug product in Canada.
German Regulatory authority BFR—The Federal Institute for Drugs and Medical Devices (Bundesinstitut für Arzneimittel und Medizinprodukte, BfArM) An independent federal authority within the portfolio of the Federal Ministry of Health involved in the tasks of licensing, improving the safety of medicinal products, detecting and evaluating the risks of medical devices, and monitoring the legal traffic in narcotic drugs and precursors.
Swiss Medic—Swiss authority for the licensing and monitoring of therapeutic products.
Australia TGA—As part of the Australian Department of Health, the TGA safeguards and enhances the health of the Australian community through effective and timely regulation of therapeutic goods.
Japan PMDA—Japanese Pharmaceuticals and Medical Devices Agency.

Food Specific Regulatory Information

EFSA—European agency for food risk assessment. Independent from individual regulatory bodies for overall advice and risk management in Europe. Most of EFSA’s work is undertaken in response to requests for scientific advice from the European Commission, the European Parliament and EU Member States.
Joint FAO/WHO Expert Committee on Food Additives/Evaluations of food additives and contaminants—The contents are the result of the deliberations of the Joint FAO/WHO Expert Committee on Food Additives which met in December 1964; including a biological and chemical overview with daily intake limits by WHO/FAO expert committee.
UK Food Standards Agency—Regulatory body for food enforcement and regulation in UK with options for alerts and up-to-date information.
US FDA Center for Food Safety and Nutrition—include, information on recalls, contaminants, compliance, guidance, supplements, and news.
US FDA GRAS Substances (SCOGS [Select Committee on GRAS Substances]) Database—Direct access to a database with opinions and conclusions from 115 SCOGS reports published between 1972–1980 on the safety of over 370 GRAS food substances.

Harmonized Regulatory Guidances—ICH and OECD

ICH—The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) brings together the regulatory authorities and pharmaceutical industry to discuss scientific and technical aspects of drug registration. Its’ mission is to make recommendations towards achieving greater harmonisation in the interpretation and application of technical guidelines and requirements for pharmaceutical product registration and the maintenance of such registrations;
ICH Safety guidances —A comprehensive set of nonclinical safety guidelines to uncover potential risks like carcinogenicity, genotoxicity and reproductive toxicity.
ICH Multidisciplinary guidances—Cross-functional topics which do not fit uniquely into one of the Quality, Safety and Efficacy categories. Includes the ICH medical terminology (MedDRA), the Common Technical Document (CTD)
OECD—The Organisation for Economic Co-operation and Development OECD provides a forum in which governments can work together to share experiences and seek solutions to common problems. OECD sets international standards on a wide range of things, from agriculture and tax to the safety of chemicals.
OECD guidelines for testing chemicals (Section 4 [of 5] on health effects)—The OECD Guidelines for the Testing of Chemicals is a collection of about 150 of the most relevant internationally agreed testing methods used by government, industry and independent laboratories to identify and characterise potential hazards of chemicals.

Toxicological Risk Assessment Additives/Excipients/Extractables/Leachables

FDA inactive ingredients approved for use in drug products—Searchable list of inactive ingredients for approved drug products operated by the FDA.
FDA Substance Registration System—Unique Ingredient Identifier; National Library of Medicine website.
Toxicology Excellence for Risk Assessment (TERA)—TERA is an independent, nonprofit organization dedicated to scientific collaboration and transparency in support of public health protection.
OECD QSAR Tool Box—Software for grouping chemicals into categories and filling gaps in (eco) toxicity data needed for assessing the hazards of chemicals. Enables robust hazard assessment through mechanistic comparisons without testing.

Public Health

Environmental Protection Agency (EPA) ACToR datawarehouse—Searchable database for all publicly available chemical toxicity data, including ToxCastDB, DSStox, and Exposure Data, operated by the US EPA. ACToR is also the data and web applications warehouse for EPA’s computational toxicology information which includes high-throughput screening, chemical exposure, sustainable chemistry (chemical structures and physicochemical properties) and virtual tissues data.
EPA Integrated Risk Information System—Searchable database for environmental toxicants, preferred source of toxicity information for the EPA and maintained by that agency.
California OEHHA (Proposition 65)—Proposition 65 (Safe Drinking Water and Toxic Enforcement Act of 1986) protects the state’s drinking water sources from being contaminated with chemicals known to cause cancer, birth defects or other reproductive harm, and requires businesses to inform Californians about exposures to such chemicals.
European Chemicals Agency—European agency providing guidance for industry for human health and the environment, operates independently from EU Commission. ECHA helps companies to comply with the legislation, advances the safe use of chemicals, provides information on chemicals and addresses chemicals of concern.
Household products—Health and safety information on Household products; site managed by the Consumer Product Information Database.
IARC monograph—International Agency for Research on Cancer; The publications program of the International Agency for Research on Cancer (IARC) is an integral part of its mission to promote international collaboration in cancer research for cancer prevention.
Chemical Safety WHO—Through the International Programme on Chemical Safety (IPCS), WHO works to establish the scientific basis for the sound management of chemicals, and to strengthen national capabilities and capacities for chemical safety.
Agency for Toxic Substances and Disease Registry (ATSDR)—A US federal public health agency that serves the public by using the best science, taking responsive public health actions, and providing trusted health information to prevent harmful exposures and diseases related to toxic substances.
Center for Disease Control (CDC) Public Health Image Library (PHIL)—PHIL offers an organized, universal electronic gateway to CDC’s pictures.
European CDC—ECDC’s mission is to identify, assess and communicate current and emerging threats to human health posed by infectious diseases.
Pathogen Safety Data Sheets and Risk Assessment (Public Health Agency of Canada)—Technical documents that describe the hazardous properties of a human pathogen and recommendations for work involving these agents in a laboratory setting.
Department of Justice (DOJ) Drug Enforcement (DEA) Office of Diversion Control—DEA’s Office of Diversion Control prevents, detects, and investigates the diversion of controlled pharmaceuticals and listed chemicals from legitimate sources while ensuring an adequate and uninterrupted supply for legitimate medical, commercial, and scientific needs.

Animal Welfare

OLAW (Office of Laboratory Animal Welfare) of the NIH—Provides guidance and interpretation of the Public Health Service Policy on Humane Care and Use of Laboratory Animals and monitors compliance with Policy to ensure the humane care and use of animals.
Animal Welfare of USDA APHIS (United States Department of Agriculture, Animal and Plant Health Inspection Service)—USDA Animal Care is responsible for upholding and enforcing the Animal Welfare Act and its associated regulations for the care and treatment of certain animals used in research.
AAALAC International (Association for the Assessment & Accreditation of Laboratory Animal Care) International—A private, nonprofit organization that promotes the humane treatment of animals in science through voluntary accreditation and assessment programs.
AALAS (American Association for Laboratory Animal Science), Learning Library, IACUC & The Guide—An association of professionals that advances responsible laboratory animal care and use to benefit people and animals. The 8th Edition of the Guide for the Care and Use of Laboratory Animals (NRC 2011) is available for download of one personal-use PDF copy.
Animal Welfare Information Center (AWIC) of the USDA NAL (United States Department of Agriculture, National Agricultural Library)—AWIC is mandated by the Animal Welfare Act (AWA) to provide information for improved animal care and use in research, testing, and teaching.
Foundation for Biomedical Research—The nation’s oldest and largest organization dedicated to improving human and animal health by promoting public understanding and support for humane and responsible animal research.

Other Professional/Educational Societies

DIA (the Drug Information Association)—Global organization dedicated to bringing health care product development professionals together in a trusted, global, neutral environment to share insights and drive action in health care product development and life cycle management.
Society of Toxicology—A professional and scholarly organization of scientists from academic institutions, government, and industry representing the variety of scientists who practice toxicology in the US and abroad. The Society’s mission is to create a safer and healthier world by advancing the science and increasing the impact of toxicology.
RAPS (Regulatory Affairs Professional Society)—An organization of and for those involved with the regulation of healthcare and related products, including medical devices, pharmaceuticals, biologics and nutritional products.
The Society for Birth Defects Research and Prevention—The Society’s Mission is to prevent birth defects and disorders of developmental origin by promoting research and exchange of ideas, communicating information to health professionals and other interested parties, and providing education and training.
ABT (American Board of Toxicology, Inc.)—The purpose of the ABT is to encourage the study of the science of toxicology, to stimulate its advancement by establishing standards for professional practice, to prepare and administer procedures including tests for the implementation of such standards, and to confer recognition by certificates or otherwise upon those members of the profession who, measured against such standards, demonstrate competence.
Scientific Liaison Coalition—Society with the mission of strengthening partnerships among scientific and health-based organizations to increase awareness of the impact of toxicology and related subjects on human health.
PhRMA—The Pharmaceutical Research and Manufactures of America (PhRMA) represents the country’s leading biopharmaceutical research companies and supports the search for new treatments and cures.
PERI (Pharmaceutical Education & Research Institute)—Organization focused on optimizing health care product development and foster professional growth.
Pharma Training International—a global interactive training partner committed to the personal progression of aspiring life science professionals.
American College of Medical Toxicology—Organization to advance the science and practice of medical toxicology (overdose, chemical exposure, envenomation)—represents physician board certification.